The SpotBot from ArrayIt costs 18,000. Important add-on is the wash station (dips the needle in a sonicator bath) for $2,600. When working with proteins cooling may be important ($8,000 add on).

The SpotBot has excellent precision (better than 10 microns) once it finds the first spot place. The trick is this initial alignment. The smallest spotter needle gives ~ 50 micron diameter. Hydrophobic surfaces stop the spots from getting bigger.

The Nanoprint from ArrayIt is set up to work with fuducials but the equipment costs ~ $100,000.


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