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In a collaborative effort, the Arthritis National Research Foundation (ANRF) and the American Federation for Aging Research (AFAR) are seeking grant applications that focus on studying the underlying mechanisms by which aging processes contribute to the development of arthritis. Studies are encouraged on the role of one or more of the hallmarks of aging that include mitochondrial dysfunction, genomic instability, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, cellular senescence, stem cell exhaustion, telomere attrition and altered intercellular communication. Successful applications will utilize cell, tissue and animal model systems or human populations that allow for the study of the aging aspects of the condition of interest.
Priority will be given to meritorious applications from newer, M.D. and/or Ph.D. applicants in early stage career development (equivalent to assistant professor and without serving as PI on an NIH R01 award).