Funding agency: 
The G. Harold & Leila Y. Mathers Foundation

The mission of the G. Harold and Leila Y. Mathers Foundation is to advance knowledge in the life sciences by sponsoring scientific research and applying learnings and discoveries to benefit mankind. Molecular-based basic scientific research is central to this goal and fundamental to our operating principles.

Funding varies by project up to $600K; average award amount is about $250K. Preference for research that is not currently NIH funded.

Current projects include: 
  • Molecular Gycobiology
  • Exploring how cells respond to signaling molecules: Synthetic cell surface receptors that control signal
  • Applying nano-physics to epigenetics: solving the structure of Piwi-pi-RNA-Chromatin complex by atomic force
  • The neuron-specific epigenome
  • Nanoscale observation and manipulation of in cells and in vivo
  • Development of gene editing technologies to cure hematopoietic related diseases
  • The mouse brain architecture project
  • Mechanism and regulation of cohesion establishment in human cells
  • Cell biology in vivo: imaging lipid transport processes within live organs
  • Protein dynamics, folding, function, and evolution
Previous projects included:
  • Temporal behaviors and physiologic systems, fractal geometry, and chaos theory
  • Pursuing consciousness into the medial temporal lobe: a combined computational electrophysiological and imaging approach
  • Program in 3-D human cell behavior
  • Transformation of sensory-motor representations by state dependent modulation
  • Imaging functional networks in vivi using small molecular probes
  • Electron microscopic reconstruction of the c-elegans male nervoussystem
  • Study of cytokinesis and cell physiology
  • Memory storage in cells outside the brain
  • Statistical physics of condensation of globular proteins  
  • A multilevel approach to determine the role of dopamine in reward-based learning
  • The effect of internal states of behavior
  • Development of rapid, micro-scale technologies for increasing throughput in protein expression, purification and structure determination
  • Immune genes: a molecular brake for synaptic plasticity
  • Sialic acids: the comparative glycobiology of the great ape
  • An integrated experimental and modelling approach to understand embryonic form: the vertebrate heart
  • Employing genomic and genetic assays to identify sense-anitsense genes
  • Early vertebrate morphogenesis: how large-scale tissue design relates to cellular-level and biomechanical responses and feedback
  • The study of determinants of amyloid structure and how to control them using NMR spectroscopy of encapsulated proteins in low viscosity fluids
  • An astrocytic basis for humanity
  • The neural basis of consciousness: implications for neurobiology
  • To develop the technology to determine and study genetic factors responsible for mammalian diversity and innovation
  • Population codes and plasticity in the accessory olfactory system
  • Investigating the prion formation of neuronal C P E B
  • Glial cell fate and function: the effect of changes in DNA copy number during development
  • Deciphering the molecular language of prion strains
  • The role of the master gene piwi in controlling the epigenetic programming of stem cells
  • Research in brain function: investigating instinct and primordial emotions using methods of system biology
  • Neural network for wakeful consciousness
  • Period protein complexes of the mammalian circadian clock
  • Line retrotranspositions and neuronal diversity in the mammalian brain
  • Capillary evaporation and bubble gating in ion channels
  • Probing the fundamental nature of bioelectric signals that mediate information processing in cells and tissues
  • Sialic acids: sperm surface glycans and reproductive compatibility
  • A unified hypothesis to explain speciation
  • Investigation of the role of protein assembly into early signaling complexes
  • Cellular correlates of human consciousness: neuronal quantification of cortical areas associated with awareness
  • The inheritance of acquired characters in mammals
  • Mechanical communication between the nucleus and cytoplasm
  • Connecting chromatin to the lumen: making pores in the nuclear envelope
  • Mapping long-range neuronal circuits in the postmortem human brain
  • Mechanism and regulation of cohesion establishment in human cells
  • Deciphering native genome organization in four dimensions
December 1, 2018
Funding type: