- Outreach and Impact
- My Science
The main goal of this Young Investigator fellowship is to select a project coordinated by a researcher working in the field of nanomaterials and radiosensitization, for the standardization of tumor models for tests with nanomaterials and radiopharmaceuticals at the Center of Chemistry and Environment of the Institute of Energetic and Nuclear Research-IPEN, based in São Paulo, Brazil.
The investigation must be directed towards an in vitro and in vivo evaluation of metal-protein hybrid nanoparticles and their interactions with high-energy radiation for the treatment of tumors. We reinforce that the project must focus mainly on the radiosensitization effects of gold and palladium nanoparticles when irradiated with gamma photons, accelerated electrons, or proton beam, and especially emphasize the chemical and biomolecular effects on tumor cells. Additionally, the performance of 198Au e 103Pd must also be investigated in the proposed tumor models. The present project proposes the establishment of an experimental oncology and nanotechnology research line at IPEN’s Center of Chemistry and Environment, and the consequent structuring of a laboratory which will support the different research centers of the Institute involved in the project.